Description
ARA290 (Cibinetide)
ARA290 (also known as Cibinetide) is a synthetic, 11-amino acid peptide derived from the helix B domain of erythropoietin (EPO). Engineered as a highly selective tissue-protective agent, ARA290 acts exclusively as an agonist of the Innate Repair Receptor (IRR)—a heterocomplex consisting of the erythropoietin receptor and CD131. Unlike full-length erythropoietin, this structural fragment stimulates cytoprotective and anti-inflammatory cellular cascades without inducing erythropoiesis or changing hematocrit parameters. [1, 2, 3]
Product Specifications
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- CAS Number: 1208243-50-8
- Chemical Formula: C₅₁H₈₄N₁₆O₂₁
- Molecular Weight: 1257.3 g/mol
- Sequence: Pyroglutamate-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser
- Appearance: White lyophilized powder
- Purity: ≥ 99% (Verified by HPLC/MS analysis) [1]
Core Research Applications
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- Innate Repair Receptor (IRR) Signaling: Utilized in vitro to map cytoprotective pathways and the downstream down-regulation of pro-inflammatory cytokines like TNF-α and IL-6. [1]
- Neural & Small Fiber Protection: Extensively researched in preclinical neurobiology models to investigate structural corneal nerve fiber density preservation and the alleviation of localized small-fiber neuropathic conditions. [1, 2]
- Islet Cell Engraftment & Ischemia: Studied for its role in mitigating environmental stress, cellular apoptosis, and improving viability parameters during intraportal islet transplantation research. [1]
FOR RESEARCH PURPOSES ONLY. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
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