GLP-2 TZ – 20mg

GLP-2 TZ (frequently referred to in literature by its chemical name, tirzepatide) is a synthetic, 39-amino-acid linear peptide that functions as a highly potent dual GIP and GLP-1 receptor agonist. Within research designation frameworks, the “2” signifies its unique ability to concurrently target two distinct incretin pathways. It is engineered as an imbalanced, biased agonist, exhibiting a structural affinity for the Glucose-dependent Insulinotropic Polypeptide (GIP) receptor equal to native GIP, while maintaining a partial, cAMP-biased activation profile at the Glucagon-Like Peptide-1 (GLP-1) receptor. This dual-pathway mechanism allows researchers to study complex multi-receptor metabolic handling, glucose regulation, and energy balance in advanced laboratory models. [1, 2, 3, 4, 5]

Key Features & Characteristics

• Mechanism of Action: Dual agonist that binds concurrently to GIP and GLP-1 receptors to trigger additive metabolic cascades. [1, 2]
• Biased Signaling Profile: Maintained structure favors native-like GIP receptor affinity over standard GLP-1 receptor activation, minimizing rapid cellular receptor internalization. [1, 2]
• Extended Pharmacokinetics: Features a C20 fatty diacid sidechain at the C-terminus that facilitates reversible albumin binding, extending its experimental half-life to approximately 120 hours. [1]
• Proteolytic Stability: Modified with an aminoisobutyric acid (Aib) substitution at position 2 to render the peptide completely resistant to rapid DPP-4 enzymatic breakdown. [1]
• Physical Form: Supplied as an ultra-pure, high-fidelity lyophilized white powder engineered for stable storage prior to laboratory reconstitution. [1]

Primary Research Applications

• Synergistic Incretin Dynamics: Extensively studied to evaluate how combining a secondary GIP pathway influences insulin secretion, lipid clearance, and energy expenditure relative to standalone GLP-1 signaling.
• Appetite and Gastric Homeostasis: Investigated in neurological and gastrointestinal models to chart how dual receptor binding modulates central satiety centers while tracking changes in gastric emptying delays.
• Adipose and Metabolic Regulation: Used in preclinical metabolic syndrome studies to observe changes in visceral fat deposition, lipid oxidation pathways, insulin sensitivity, and overall body composition changes. [1, 2, 3, 4]

For Research Use Only. Not for human consumption, therapeutic, or diagnostic use.