KPV – 10mg

KPV is a naturally occurring, highly potent anti-inflammatory tripeptide consisting of the amino acid sequence Lysine-Proline-Valine. It represents the specific C-terminal fragment of alpha-Melanocyte-Stimulating Hormone (α-MSH). KPV achieves its biological effects independently of classic melanocortin receptors (MC1R–MC5R), meaning it does not alter skin pigmentation. Instead, it enters cells directly to interact with nuclear signaling pathways, making it a primary compound in immunological and gastroenterological research for investigating structural inflammation and mucosal repair.

Key Features & Characteristics

• Mechanism of Action: Translocates into the cell nucleus to inhibit NF-κB (Nuclear Factor kappa B), the master genetic switch that drives inflammatory cytokine production.
• Non-Melanotropic Structure: Lacks the specific core sequence required to activate pigment-producing receptors, ensuring isolated anti-inflammatory pathways.
• Antimicrobial Properties: Exhibits direct structural disruption against certain fungal and bacterial pathogens, preventing them from forming biofilms.
• Physical Form: Produced via high-fidelity chemical synthesis and provided as an ultra-pure, white lyophilized powder requiring laboratory reconstitution.

Primary Research Applications

• Inflammatory Bowel Disease (IBD): Extensively studied in gastrointestinal models to observe the reduction of colitis symptoms, the restoration of intestinal mucosal linings, and the calming of gut-wall inflammation.
• Dermatological Repair: Investigated in inflammatory skin models (such as psoriasis and dermatitis) to monitor its ability to suppress local swelling, accelerate epidermal healing, and reduce scar formation.
• Systemic Cytokine Control: Evaluated in broad immune system models to observe its capacity to downregulate pro-inflammatory signaling proteins like TNF-α, IL-1β, and IL-6.

For Research Use Only. Not for human consumption, therapeutic, or diagnostic use.