MOTS-c(Human) – 20mg

MOTS-c (Human)

—or Mitochondrial ORF of the 12S rRNA Type-C—is a novel, 16-amino-acid mitochondrial-derived peptide (MDP). It represents a paradigm shift in cellular biology, demonstrating that mitochondria possess their own short open reading frames (sORFs) to encode functional signaling peptides that communicate directly with the nuclear genome. Frequently categorized in literature as an “exercise mimetic,” MOTS-c translocates to the cell nucleus during states of metabolic or oxidative stress. There, it activates vital energy-sensing pathways to regulate cellular metabolism, systemic insulin sensitivity, and physical endurance thresholds in laboratory models. [1, 2, 3, 4, 5, 6, 7]

Key Features & Characteristics

• Mechanism of Action: Activates the AMPK (Adenosine Monophosphate-Activated Protein Kinase) pathway via the folate-purine-AICAR signaling cascade to enhance cellular energy tracking. [1, 2]
• Retrograde Nuclear Signaling: Uniquely migrates from the mitochondria to the nucleus under stress conditions to direct adaptive gene expression patterns. [1, 2]
• Skeletal Muscle Targeting: Promotes insulin-independent glucose uptake directly inside skeletal muscle tissue by upregulating glycolysis dynamics. [1, 2, 3]
• Physical Form: Produced via high-fidelity chemical synthesis to match the native human sequence and supplied as a highly stable, white lyophilized powder. [1, 2]

Primary Research Applications

• Metabolic Syndrome & Homeostasis: Extensively studied in diet-induced obesity and type 2 diabetes models to observe changes in fatty acid oxidation, visceral adipose tissue accumulation, and insulin resistance biomarkers.
• Physical Performance & Muscle Decline: Investigated in aging animal models to track the reversal of age-dependent sarcopenia (muscle wasting) and the restoration of physical grip strength and endurance.
• Longevity & Osteoblast Metabolism: Evaluated for its structural capacity to slow cellular senescence, suppress chronic systemic inflammation, and regulate bone remodeling by stimulating osteoblast differentiation. [1, 2, 3, 4, 5, 6]

For Research Use Only. Not for human consumption, therapeutic, or diagnostic use.

https://www.youtube.com/watch?v=_b9Av7aTqas