Semax – 10mg

Semax is a synthetic heptapeptide analog of the adrenocorticotropic hormone fragment ACTH(4-10). Originally developed in the 1980s and 1990s, it consists of the core amino acid sequence Met-Glu-His-Phe-Arg-Gly-Pro. The addition of the C-terminal Gly-Pro dipeptide provides remarkable metabolic stability, preventing rapid degradation by central nervous system proteases and peptidyl peptidases. Functioning as a non-hormonal, neuro-specific modulator, Semax easily crosses the blood-brain barrier to influence central neurotransmitter systems, neurotrophic factors, and brain circulation networks in advanced neurological research.

Key Features & Characteristics

• Mechanism of Action: Modulates the expression of central monoamines (serotonin, dopamine, and norepinephrine) and activates specific melanocortin receptor pathways.
• Neurotrophic Support: Rapidly upregulates the synthesis of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) in brain tissue cells.
• Structural Optimization: The Proline-Glycine-Proline extension safeguards the peptide chain, granting a significantly prolonged half-life in cerebrospinal fluid over native ACTH fragments.
• Physical Form: Produced via high-fidelity peptide synthesis and supplied as a highly stable, white lyophilized powder requiring precise laboratory reconstitution.

Primary Research Applications

• Cognitive Enhancement & Focus: Extensively studied in animal behavioral assays to analyze improvements in learning capacity, exploratory behavior, exploratory focus, and short-term memory consolidation under stress.
• Ischemic Recovery & Neuroprotection: Investigated in stroke and cerebral hypoxia models to observe how the peptide mitigates neuronal apoptosis, counters oxidative stress, and preserves neural architecture.
• Immunomodulatory & Anti-Stress Networks: Evaluated for its capacity to regulate localized cytokine balances and stabilize central nervous pathways during acute emotional or physical stress induction.

For Research Use Only. Not for human consumption, therapeutic, or diagnostic use