TB500 – 10mg

TB-500 is a synthetic, short-chain peptide analog of the naturally occurring protein Thymosin Beta-4 (Tβ4). Consisting of the specific amino acid sequence representing the core functional domain of the parent molecule (specifically fragments 17–23), it acts as a primary actin-sequestering agent within cellular environments. Because of its ultra-low molecular weight, TB-500 possesses extraordinary systemic mobility and tissue penetration compared to full-length proteins. It is widely utilized in cellular biology and tissue engineering research to study accelerated wound repair, vascular growth, and cellular migration cascades.

Key Features & Characteristics

• Mechanism of Action: Binds directly to G-actin (monomeric actin) to inhibit its polymerization into F-actin filaments, a crucial mechanism that drives cellular structural remodeling and motility.
• Systemic Mobility: Lacks the larger, secondary protein folds of whole Thymosin Beta-4, allowing the molecule to diffuse easily through tissue boundaries and travel systemically to target sites in animal models.
• Angiogenic Induction: Stimulates the migration of endothelial cells to promote the formation of new capillary networks from pre-existing blood vessels.
• Physical Form: Produced via high-purity solid-phase synthesis and supplied as a stable, white lyophilized powder ready for precise laboratory fluid dissolution.

Primary Research Applications

• Soft Tissue & Tendon Regeneration: Extensively investigated in sports medicine and musculoskeletal research to study the healing speed of severe tendon, ligament, and muscle fiber tears.
• Cardioprotection & Ischemic Remodeling: Investigated in myocardial injury models to observe how the peptide encourages cell migration, limits scar tissue formation, and supports cellular survival after oxygen deprivation.
• Dermal Repair & Anti-Inflammatory Signaling: Used in acute wound and burn research models to track the down-regulation of pro-inflammatory cytokines while accelerating re-epithelialization rates.

For Research Use Only. Not for human consumption, therapeutic, or diagnostic use.