VIP – 10mg

VIP

(Vasoactive Intestinal Peptide) is a naturally occurring, 28-amino-acid neuroregulatory peptide that functions as a powerful hormone, neuromodulator, and cytokine balancer. Synthesized within the central nervous system, gastrointestinal tract, and immune cells, it plays a vital role in maintaining systemic homeostasis. In preclinical research, VIP is highly valued for its dual functionality: it serves as a potent endogenous vasodilator and acts as a major anti-inflammatory agent, making it a critical tool for studying complex neuro-immune signaling networks and tissue barrier integrity.

Key Features & Characteristics

• Mechanism of Action: Binds with high affinity to two specific G-protein coupled receptors, VPAC1 and VPAC2, to trigger intracellular cAMP accumulation.
• Neuro-Immune Balance: Functions as a natural brake on the immune system, shifting cellular responses away from pro-inflammatory configurations.
• Vascular Smooth Muscle Relaxation: Induces powerful, receptor-mediated vasodilation in peripheral and pulmonary vascular beds without causing localized cell destruction.
• Physical Form: Synthesized to maximum chemical purity and provided as a highly stable, white lyophilized powder requiring precise fluid reconstitution.

Primary Research Applications

• Pulmonary Homeostasis & Fibrosis: Heavily studied in respiratory models to evaluate its capacity to reduce pulmonary arterial pressure, relax bronchial smooth muscle, and mitigate chronic tissue remodeling or fibrosis.
• Gastrointestinal Motility & Barrier Integrity: Investigated in inflammatory bowel disease (IBD) and colitis models to observe its role in regulating gastric secretions, controlling smooth muscle motility, and repairing mucosal linings.
• Neuroprotection & Blood-Brain Barrier (BBB): Evaluated in neurodegenerative research to track how it suppresses microglial overactivation, shields neuronal structures from oxidative stress, and maintains tight junction integrity in the BBB.

For Research Use Only. Not for human consumption, therapeutic, or diagnostic use.