Nad+ ( 500mg )

NAD+

(Nicotinamide Adenine Dinucleotide) is an essential coenzyme found in all living cells, serving as a critical cofactor for cellular energy production, mitochondrial health, and DNA repair mechanisms. It exists in two cellular states: its active oxidized form (NAD+) and its reduced form (NADH). Within laboratory and cellular models, maintaining an optimal NAD+/NADH ratio is vital for driving the electron transport chain to generate adenosine triphosphate (ATP), making it a cornerstone molecule in research focused on mitochondrial function, metabolic regulation, and cellular longevity.

Key Features & Characteristics

• Mechanism of Action: Functions as a primary electron transporter in glycolysis, the Krebs cycle, and oxidative phosphorylation to catalyze cellular energy production.
• Enzymatic Substrate: Serves as an indispensable substrate consumed by sirtuins (SIRT1-7), poly(ADP-ribose) polymerases (PARPs), and CD38 to regulate epigenetic silencing and genomic stability.
• Salvage Pathway Target: Interacts with cellular precursors like NMN and NR to chart the efficiency of the NAD+ salvage pathway in animal tissues.
• Physical Form: Highly purified and supplied as a stable, moisture-sensitive crystalline powder or lyophilized cake requiring protected laboratory storage.

Primary Research Applications

• Mitochondrial Biogenesis & Aging: Heavily utilized in gerontological research to study the reversal of age-related mitochondrial decay, the suppression of cellular senescence, and cell lifespan extension.
• Metabolic Syndrome Models: Investigated in obesity and insulin resistance models to observe how raising intracellular NAD+ levels influences lipid metabolism and systemic energy expenditure.
• Neuroprotection & Repair: Evaluated in neurological injury assays to track the protection of axonal structures, reduction of neuroinflammation, and modulation of cognitive decline biomarkers under oxidative stress.

For Research Use Only. Not for human consumption, therapeutic, or diagnostic use.